Via delle Coppelle was born as an axis on which the historical fabric of Imperial Rome developed in the Campo Marzio area to connect this area to the Tiber river on the Ripetta port. Over the decades this space has always played a pivotal role: the current Palazzo delle Pietre was originally erected prior to the 1400s, at the famous Alexandrian Baths - ex Neroniane - built in 62 A.D., and was in use until the 5th century A.D.; it was talked about it in the Middle Ages, when it witnessed the creation of the "Via Recta" which, retracing the Roman route, aimed at taking the pilgrims from the centre, passing through Via delle Coppelle, up to San Pietro. In the 15th century, the body of Via delle Coppelle was bound to the name of the Vatican Archconfraternity of the Santissima Annunziata and remained its property until the mid-nineteenth century. In the nineteenth and twentieth centuries, there were several changes of ownership of the premises belonging to the Santissima Annunziata which were split into various buildings. The Palazzo delle Pietre was purchased by the Mazzi family in 2012, and was in a state of total neglect.